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USP10 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14694
Clone Names 100507179
Peptide ID 100507179
Additional Information
Gene ID 9100
Other Names Ubiquitin carboxyl-terminal hydrolase 10, Deubiquitinating enzyme 10, Ubiquitin thioesterase 10, Ubiquitin-specific-processing protease 10, USP10, KIAA0190
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP10
Synonyms KIAA0190
Function Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
Cellular Location Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Ubiquitin is a highly conserved protein that is covalentlylinked to other proteins to regulate their function anddegradation. This gene encodes a member of the ubiquitin-specificprotease family of cysteine proteases. The enzyme specificallycleaves ubiquitin from ubiquitin-conjugated protein substrates. Theprotein is found in the nucleus and cytoplasm. It functions as aco-factor of the DNA-bound androgen receptor complex, and isinhibited by a protein in the Ras-GTPase pathway. The human genomecontains several pseudogenes similar to this gene. [provided byRefSeq].


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yuan, J., et al. Cell 140(3):384-396(2010)Bomberger, J.M., et al. J. Biol. Chem. 284(28):18778-18789(2009)Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 80.00
Cat# BP17199c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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