Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
PPP1R13B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96KQ4 |
|---|---|
| Clone Names | 100507184 |
| Gene ID | 23368 |
|---|---|
| Other Names | Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B, PPP1R13B, ASPP1, KIAA0771 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPP1R13B |
|---|---|
| Synonyms | ASPP1, KIAA0771 |
| Function | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear |
| Tissue Location | Reduced expression in breast carcinomas expressing a wild-type TP53 protein. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the ASPP(apoptosis-stimulating protein of p53) family of p53 interactingproteins. The protein contains four ankyrin repeats and an SH3domain involved in protein-protein interactions. ASPP proteins arerequired for the induction of apoptosis by p53-family proteins.They promote DNA binding and transactivation of p53-family proteinson the promoters of proapoptotic genes. Expression of this gene isregulated by the E2F transcription factor.
References
Figl, A., et al. Mutat. Res. 702(1):8-16(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zhao, J., et al. Hepatology 51(1):142-153(2010)Agirre, X., et al. Oncogene 25(13):1862-1870(2006)Liu, Z.J., et al. Biochim. Biophys. Acta 1756(1):77-80(2005)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
