|Other Names||Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13B, PPP1R13B, ASPP1, KIAA0771|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear|
|Tissue Location||Reduced expression in breast carcinomas expressing a wild-type TP53 protein|
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This gene encodes a member of the ASPP(apoptosis-stimulating protein of p53) family of p53 interactingproteins. The protein contains four ankyrin repeats and an SH3domain involved in protein-protein interactions. ASPP proteins arerequired for the induction of apoptosis by p53-family proteins.They promote DNA binding and transactivation of p53-family proteinson the promoters of proapoptotic genes. Expression of this gene isregulated by the E2F transcription factor.
Figl, A., et al. Mutat. Res. 702(1):8-16(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zhao, J., et al. Hepatology 51(1):142-153(2010)Agirre, X., et al. Oncogene 25(13):1862-1870(2006)Liu, Z.J., et al. Biochim. Biophys. Acta 1756(1):77-80(2005)
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