|Other Names||Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, Signal-regulatory protein alpha-2, Sirp-alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-3, p84, CD172a, SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP|
|Function||Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas|
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The protein encoded by this gene is a member of thesignal-regulatory-protein (SIRP) family, and also belongs to theimmunoglobulin superfamily. SIRP family members are receptor-typetransmembrane glycoproteins known to be involved in the negativeregulation of receptor tyrosine kinase-coupled signaling processes.This protein can be phosphorylated by tyrosine kinases. Thephospho-tyrosine residues of this PTP have been shown to recruitSH2 domain containing tyrosine phosphatases (PTP), and serve assubstrates of PTPs. This protein was found to participate in signaltransduction mediated by various growth factor receptors. CD47 hasbeen demonstrated to be a ligand for this receptor protein. Thisgene and its product share very high similarity with several othermembers of the SIRP family. These related genes are located inclose proximity to each other on chromosome 20p13. Multiplealternatively spliced transcript variants have been determined forthis gene.
Shen, X., et al. J. Biol. Chem. 285(38):29416-29424(2010)Kapoor, G.S., et al. Oncogene 29(29):4130-4144(2010)Tsai, R.K., et al. Blood Cells Mol. Dis. 45(1):67-74(2010)Radhakrishnan, Y., et al. J. Biol. Chem. 285(21):15682-15695(2010)de Almeida, A.C., et al. Immunopharmacol Immunotoxicol 31(4):636-640(2009)
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