|Other Names||RNA-binding motif, single-stranded-interacting protein 1, Single-stranded DNA-binding protein MSSP-1, Suppressor of CDC2 with RNA-binding motif 2, RBMS1, C2orf12, MSSP, MSSP1, SCR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C2orf12, MSSP, MSSP1, SCR2|
|Function||Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication.|
|Tissue Location||Highest amounts are found in placenta, lung and heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a small family of proteinswhich bind single stranded DNA/RNA. These proteins arecharacterized by the presence of two sets of ribonucleoproteinconsensus sequence (RNP-CS) that contain conserved motifs, RNP1 andRNP2, originally described in RNA binding proteins, and requiredfor DNA binding. These proteins have been implicated in suchdiverse functions as DNA replication, gene transcription, cellcycle progression and apoptosis. Several transcript variants,resulting from alternative splicing and encoding differentisoforms, have been described. A pseudogene for this locus is foundon chromosome 12.
Qi, L., et al. Hum. Mol. Genet. 19(13):2706-2715(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(22):9004-9009(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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