|Other Names||Syntaxin-binding protein 5, Lethal(2) giant larvae protein homolog 3, Tomosyn-1, STXBP5, LLGL3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Syntaxin 1 is a component of the 7S and 20S SNAREcomplexes which are involved in docking and fusion of synapticvesicles with the presynaptic plasma membrane. This gene encodes asyntaxin 1 binding protein. In rat, a similar protein dissociatessyntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10Scomplex, an intermediate which can be converted to the 7S SNAREcomplex. Thus this protein is thought to be involved inneurotransmitter release by stimulating SNARE complex formation.Alternatively spliced transcript variants encoding differentisoforms have been identified.
Thye, T., et al. Nat. Genet. 42(9):739-741(2010)Wu, C., et al. Pharmacogenet. Genomics 20(6):389-395(2010)Smith, N.L., et al. Circulation 121(12):1382-1392(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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