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STXBP5 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q5T5C0
Clone Names 100517225
Peptide ID 100517225
Additional Information
Gene ID 134957
Other Names Syntaxin-binding protein 5, Lethal(2) giant larvae protein homolog 3, Tomosyn-1, STXBP5, LLGL3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LLGL3
Function Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles (By similarity).
Research Areas
Citations (0)

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Syntaxin 1 is a component of the 7S and 20S SNAREcomplexes which are involved in docking and fusion of synapticvesicles with the presynaptic plasma membrane. This gene encodes asyntaxin 1 binding protein. In rat, a similar protein dissociatessyntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10Scomplex, an intermediate which can be converted to the 7S SNAREcomplex. Thus this protein is thought to be involved inneurotransmitter release by stimulating SNARE complex formation.Alternatively spliced transcript variants encoding differentisoforms have been identified.


Thye, T., et al. Nat. Genet. 42(9):739-741(2010)Wu, C., et al. Pharmacogenet. Genomics 20(6):389-395(2010)Smith, N.L., et al. Circulation 121(12):1382-1392(2010)Olsen, J.V., et al. Cell 127(3):635-648(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)

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$ 80.00
Cat# BP17209c
Availability: In Stock
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