|Other Names||Probable G-protein coupled receptor 75, GPR75|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
GPR75 is a member of the G protein-coupled receptorfamily. GPRs are cell surface receptors that activateguanine-nucleotide binding proteins upon the binding of aligand.
Tarttelin, E.E., et al. Biochem. Biophys. Res. Commun. 260(1):174-180(1999)
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