|Other Names||Ubiquitin-conjugating enzyme E2 variant 2, DDVit 1, Enterocyte differentiation-associated factor 1, EDAF-1, Enterocyte differentiation-promoting factor 1, EDPF-1, MMS2 homolog, Vitamin D3-inducible protein, UBE2V2, MMS2, UEV2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.|
|Tissue Location||Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues|
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Ubiquitin-conjugating enzyme E2 variant proteinsconstitute a distinct subfamily within the E2 protein family. Theyhave sequence similarity to other ubiquitin-conjugating enzymes butlack the conserved cysteine residue that is critical for thecatalytic activity of E2s. The protein encoded by this gene alsoshares homology with ubiquitin-conjugating enzyme E2 variant 1 andyeast MMS2 gene product. It may be involved in the differentiationof monocytes and enterocytes.
Wen, R., et al. Plant Cell 20(1):213-227(2008)Brun, J., et al. BMC Mol. Biol. 9, 24 (2008) :Pastushok, L., et al. FEBS Lett. 581(28):5343-5348(2007)Zhao, G.Y., et al. Mol. Cell 25(5):663-675(2007)Wen, R., et al. Plant Mol. Biol. 61 (1-2), 241-253 (2006) :
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