|Other Names||Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the dualspecificity protein tyrosine phosphatase family. It is highlysimilar to Saccharomyces cerevisiae Cdc14, a protein tyrosinephosphatase involved in the exit of cell mitosis and initiation ofDNA replication, suggesting a role in cell cycle control. Thisprotein has been shown to interact with, and dephosphorylate tumorsuppressor protein p53, and is thought to regulate the function ofp53. Alternative splicing of this gene results in severaltranscript variants encoding distinct isoforms. [provided byRefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Mocciaro, A., et al. J. Cell Biol. 189(4):631-639(2010)Song, S.Y., et al. APMIS 118(5):389-393(2010)Chen, J.S., et al. Biotechnol. Lett. 31(5):615-621(2009)
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