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CDC14A Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UNH5
Clone Names 100617177
Peptide ID 100617177
Additional Information
Gene ID 8556
Other Names Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A, CDC14A
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC14A
Function Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, spindle Cell projection, kinocilium {ECO:0000250|UniProtKB:Q6GQT0} Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity) {ECO:0000250|UniProtKB:Q6GQT0, ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:15263015}
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a member of the dualspecificity protein tyrosine phosphatase family. It is highlysimilar to Saccharomyces cerevisiae Cdc14, a protein tyrosinephosphatase involved in the exit of cell mitosis and initiation ofDNA replication, suggesting a role in cell cycle control. Thisprotein has been shown to interact with, and dephosphorylate tumorsuppressor protein p53, and is thought to regulate the function ofp53. Alternative splicing of this gene results in severaltranscript variants encoding distinct isoforms. [provided byRefSeq].

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Mocciaro, A., et al. J. Cell Biol. 189(4):631-639(2010)Song, S.Y., et al. APMIS 118(5):389-393(2010)Chen, J.S., et al. Biotechnol. Lett. 31(5):615-621(2009)

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$ 80.00
Cat# BP17213b
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