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RHD Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q02161 |
|---|---|
| Clone Names | 100617234 |
| Gene ID | 6007 |
|---|---|
| Other Names | Blood group Rh(D) polypeptide, RHXIII, Rh polypeptide 2, RhPII, Rhesus D antigen, CD240D, RHD |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RHD |
|---|---|
| Function | May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Restricted to tissues or cell lines expressing erythroid characters |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Rh blood group system is the second most clinicallysignificant of the blood groups, second only to ABO. It is also themost polymorphic of the blood groups, with variations due todeletions, gene conversions, and missense mutations. The Rh bloodgroup includes this gene, which encodes the RhD protein, and asecond gene that encodes both the RhC and RhE antigens on a singlepolypeptide. The two genes, and a third unrelated gene, are foundin a cluster on chromosome 1. The classification of Rh-positive andRh-negative individuals is determined by the presence or absence ofthe highly immunogenic RhD protein on the surface of erythrocytes.Multiple transcript variants encoding different isoforms have beenfound for this gene.
References
Flegr, J., et al. Folia Parasitol. 57(2):143-150(2010)Liu, H.C., et al. Biochim. Biophys. Acta 1800(6):565-573(2010)Schmid, P., et al. Transfusion 50(1):267-269(2010)Wang, X.D., et al. Eur. J. Clin. Invest. 39(7):607-617(2009)Wagner, F.F., et al. Blood 99(6):2272-2273(2002)
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