|Other Names||fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor, FPR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a G protein-coupled receptor ofmammalian phagocytic cells that is a member of the G-proteincoupled receptor 1 family. The protein mediates the response ofphagocytic cells to invasion of the host by microorganisms and isimportant in host defense and inflammation.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Huang, J., et al. Br. J. Cancer 102(6):1052-1060(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Zhu, X.L., et al. Beijing Da Xue Xue Bao 41(6):664-668(2009)Kobayashi, T., et al. J. Dent. Res. 88(12):1137-1141(2009)
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