|Other Names||TRAF-type zinc finger domain-containing protein 1, Protein FLN29, TRAFD1, FLN29|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The innate immune system confers host defense againstviral and microbial infection, and TRAFD1 is a negative feedbackregulator that controls excessive immune responses (Sanada et al.,2008 [PubMed 18849341]).
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)Sanada, T., et al. J. Biol. Chem. 283(49):33858-33864(2008)Nature 447(7145):661-678(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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