|Other Names||E3 ubiquitin-protein ligase Praja-2, Praja2, 632-, RING finger protein 131, PJA2, KIAA0438, RNF131|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes.|
|Cellular Location||Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane.|
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Provided below are standard protocols that you may find useful for product applications.
PJA2 has E2-dependent E3 ubiquitin-protein ligase activity (By similarity).
Olsen, J.V., et al. Cell 127(3):635-648(2006)Sasaki, A., et al. J. Biol. Chem. 277(25):22541-22546(2002)Yu, P., et al. Genomics 79(6):869-874(2002)Mishra, L., et al. Oncogene 15(19):2361-2368(1997)Nakayama, M., et al. J. Neurosci. 15 (7 PT 2), 5238-5248 (1995) :
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