|Other Names||Small conductance calcium-activated potassium channel protein 1, SK1, SKCa 1, SKCa1, KCa21, KCNN1, SK|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Action potentials in vertebrate neurons are followed by anafterhyperpolarization (AHP) that may persist for several secondsand may have profound consequences for the firing pattern of theneuron. Each component of the AHP is kinetically distinct and ismediated by different calcium-activated potassium channels. Theprotein encoded by this gene is activated before membranehyperpolarization and is thought to regulate neuronal excitabilityby contributing to the slow component of synaptic AHP. The encodedprotein is an integral membrane protein that forms avoltage-independent calcium-activated channel with three othercalmodulin-binding subunits. This gene is a member of the KCNNfamily of potassium channel genes.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)Arnold, S.J., et al. Neuroreport 14(2):191-195(2003)Boettger, M.K., et al. Brain 125 (PT 2), 252-263 (2002) :Zhang, B.M., et al. Biochemistry 40(10):3189-3195(2001)
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