|Other Names||Ubiquitin-conjugating enzyme E2 Z, Uba6-specific E2 conjugating enzyme 1, Use1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, UBE2Z|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed. Highly in placenta, pancreas, spleen and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Modification of proteins with ubiquitin (UBB; MIM 191339)or ubiquitin-like proteins controls many signaling networks andrequires a ubiquitin activating enzyme (E1), a ubiquitinconjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE2Zis an E2 enzyme (Jin et al., 2007 [PubMed 17597759]).[supplied byOMIM].
Gu, X., et al. Mol. Biol. Rep. 34(3):183-188(2007)Jin, J., et al. Nature 447(7148):1135-1138(2007)
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