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ZP3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P21754
Clone Names 100623248
Peptide ID 100623248
Additional Information
Gene ID 7784
Other Names Zona pellucida sperm-binding protein 3, Sperm receptor, ZP3A/ZP3B, Zona pellucida glycoprotein 3, Zp-3, Zona pellucida protein C, Processed zona pellucida sperm-binding protein 3, ZP3, ZP3A, ZP3B, ZPC
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZP3
Synonyms ZP3A, ZP3B, ZPC
Function The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
Cellular Location Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P48833}. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.
Tissue Location Oocytes.
Research Areas
Citations (0)

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The zona pellucida is an extracellular matrix thatsurrounds the oocyte and early embryo. It is composed primarily ofthree or four glycoproteins with various functions duringfertilization and preimplantation development. The protein encodedby this gene is a structural component of the zona pellucida andfunctions in primary binding and induction of the sperm acrosomereaction. The nascent protein contains a N-terminal signal peptidesequence, a conserved ZP domain, a C-terminal consensus furincleavage site, and a transmembrane domain. It is hypothesized thatfurin cleavage results in release of the mature protein from theplasma membrane for subsequent incorporation into the zonapellucida matrix. However, the requirement for furin cleavage inthis process remains controversial based on mouse studies. Avariation in the last exon of this gene has previously served asthe basis for an additional ZP3 locus; however, sequence andliterature review reveals that there is only one full-length ZP3locus in the human genome. Another locus encoding a bipartitetranscript designated POMZP3 contains a duplication of the lastfour exons of ZP3, including the above described variation, andmaps closely to this gene.


Davila, S., et al. Genes Immun. 11(3):232-238(2010)Bansal, P., et al. Biol. Reprod. 81(1):7-15(2009)Choudhury, S., et al. J. Reprod. Immunol. 79(2):137-147(2009)Chiu, P.C., et al. Biol. Reprod. 79(5):869-877(2008)Tormala, R.M., et al. Mol. Cell. Endocrinol. 289 (1-2), 10-15 (2008) :

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$ 80.00
Cat# BP17235b
Availability: In Stock
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