|Other Names||Heterogeneous nuclear ribonucleoprotein R, hnRNP R, HNRNPR, HNRPR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
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This gene belongs to the subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has threerepeats of quasi-RRM domains that bind to RNAs and also contains anuclear localization motif. Multiple alternatively splicedtranscript variants have been found for this gene. [provided byRefSeq].
Hadian, K., et al. J. Biol. Chem. 284(48):33384-33391(2009)Fukuda, A., et al. J. Biol. Chem. 284(35):23472-23480(2009)Tonevitsky, E.A., et al. Bull. Exp. Biol. Med. 147(6):733-736(2009)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
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