|Other Names||BMP-2-inducible protein kinase, BIKe, BMP2K, BIKE|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1723a was selected from the Center region of human BIKE . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in osteoblast differentiation.|
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BIKE is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation.
Kearns, A.E., et al., J. Biol. Chem. 276(45):42213-42218 (2001).Hoffmann, A., et al., Crit. Rev. Eukaryot. Gene Expr. 11 (1-3), 23-45 (2001).
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