|Other Names||Polyadenylate-binding protein 4, PABP-4, Poly(A)-binding protein 4, Activated-platelet protein 1, APP-1, Inducible poly(A)-binding protein, iPABP, PABPC4, APP1, PABP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).|
|Cellular Location||Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
|Tissue Location||Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated|
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Poly(A)-binding proteins (PABPs) bind to the poly(A) tailpresent at the 3-prime ends of most eukaryotic mRNAs. PABPC4 orIPABP (inducible PABP) was isolated as an activation-induced T-cellmRNA encoding a protein. Activation of T cells increased PABPC4mRNA levels in T cells approximately 5-fold. PABPC4 contains 4RNA-binding domains and proline-rich C terminus. PABPC4 islocalized primarily to the cytoplasm. It is suggested that PABPC4might be necessary for regulation of stability of labile mRNAspecies in activated T cells. PABPC4 was also identified as anantigen, APP1 (activated-platelet protein-1), expressed onthrombin-activated rabbit platelets. PABPC4 may also be involved inthe regulation of protein translation in platelets andmegakaryocytes or may participate in the binding or stabilizationof polyadenylates in platelet dense granules. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.
Jonson, L., et al. Mol. Cell Proteomics 6(5):798-811(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
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