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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PABPC4 Antibody (Center) Blocking Peptide   

PABPC4 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13310
Clone Names 100712124
Peptide ID 100712124
Additional Information
Gene ID 8761
Other Names Polyadenylate-binding protein 4, PABP-4, Poly(A)-binding protein 4, Activated-platelet protein 1, APP-1, Inducible poly(A)-binding protein, iPABP, PABPC4, APP1, PABP4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms APP1, PABP4
Function Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
Cellular Location Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Tissue Location Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated
Research Areas
Citations (0)

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Poly(A)-binding proteins (PABPs) bind to the poly(A) tailpresent at the 3-prime ends of most eukaryotic mRNAs. PABPC4 orIPABP (inducible PABP) was isolated as an activation-induced T-cellmRNA encoding a protein. Activation of T cells increased PABPC4mRNA levels in T cells approximately 5-fold. PABPC4 contains 4RNA-binding domains and proline-rich C terminus. PABPC4 islocalized primarily to the cytoplasm. It is suggested that PABPC4might be necessary for regulation of stability of labile mRNAspecies in activated T cells. PABPC4 was also identified as anantigen, APP1 (activated-platelet protein-1), expressed onthrombin-activated rabbit platelets. PABPC4 may also be involved inthe regulation of protein translation in platelets andmegakaryocytes or may participate in the binding or stabilizationof polyadenylates in platelet dense granules. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.


Jonson, L., et al. Mol. Cell Proteomics 6(5):798-811(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)

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$ 80.00
Cat# BP17240c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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