|Other Names||Membrane-associated phosphatidylinositol transfer protein 1, Drosophila retinal degeneration B homolog, Phosphatidylinositol transfer protein, membrane-associated 1, PITPnm 1, Pyk2 N-terminal domain-interacting receptor 2, NIR-2, PITPNM1, DRES9, NIR2, PITPNM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DRES9, NIR2, PITPNM|
|Function||Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.|
|Cellular Location||Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Cleavage furrow. Midbody. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835)|
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Provided below are standard protocols that you may find useful for product applications.
PITPNM1 belongs to a family of membrane-associatedphosphatidylinositol transfer domain-containing proteins that sharehomology with the Drosophila retinal degeneration B (rdgB) protein(Ocaka et al., 2005 [PubMed 15627748]).
Burgis, N.E., et al. J. Biol. Chem. 282(6):3531-3538(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Litvak, V., et al. Nat. Cell Biol. 7(3):225-234(2005)Amarilio, R., et al. J. Biol. Chem. 280(7):5934-5944(2005)Ocaka, L., et al. Cytogenet. Genome Res. 108(4):293-302(2005)
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