MCC Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P23508 |
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Clone Names | 100712146 |
Gene ID | 4163 |
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Other Names | Colorectal mutant cancer protein, Protein MCC, MCC |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MCC |
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Function | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b- catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2- dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). |
Cellular Location | Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells |
Tissue Location | Expressed in a variety of tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a candidate colorectal tumor suppressor genethat is thought to negatively regulate cell cycle progression. Theorthologous gene in the mouse expresses a phosphoprotein associatedwith the plasma membrane and membrane organelles, andoverexpression of the mouse protein inhibits entry into S phase.Multiple transcript variants encoding different isoforms have beenfound for this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)Fukuyama, R., et al. Oncogene 27(46):6044-6055(2008)
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