|Other Names||Colorectal mutant cancer protein, Protein MCC, MCC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).|
|Cellular Location||Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells|
|Tissue Location||Expressed in a variety of tissues.|
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This gene is a candidate colorectal tumor suppressor genethat is thought to negatively regulate cell cycle progression. Theorthologous gene in the mouse expresses a phosphoprotein associatedwith the plasma membrane and membrane organelles, andoverexpression of the mouse protein inhibits entry into S phase.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)Fukuyama, R., et al. Oncogene 27(46):6044-6055(2008)
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