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MCC Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P23508
Clone Names 100712146
Peptide ID 100712146
Additional Information
Gene ID 4163
Other Names Colorectal mutant cancer protein, Protein MCC, MCC
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCC
Function Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
Cellular Location Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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This gene is a candidate colorectal tumor suppressor genethat is thought to negatively regulate cell cycle progression. Theorthologous gene in the mouse expresses a phosphoprotein associatedwith the plasma membrane and membrane organelles, andoverexpression of the mouse protein inhibits entry into S phase.Multiple transcript variants encoding different isoforms have beenfound for this gene.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)Fukuyama, R., et al. Oncogene 27(46):6044-6055(2008)

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$ 80.00
Cat# BP17244c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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