|Other Names||Lysyl oxidase homolog 4, 143-, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C, LOXL4, LOXC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May modulate the formation of a collagenous extracellular matrix.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage|
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This gene encodes a member of the lysyl oxidase genefamily. The prototypic member of the family is essential to thebiogenesis of connective tissue, encoding an extracellularcopper-dependent amine oxidase that catalyses the first step in theformation of crosslinks in collagens and elastin. A highlyconserved amino acid sequence at the C-terminus end appears to besufficient for amine oxidase activity, suggesting that each familymember may retain this function. The N-terminus is poorly conservedand may impart additional roles in developmental regulation,senescence, tumor suppression, cell growth control, and chemotaxisto each member of the family.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Sebban, S., et al. Virchows Arch. 454(1):71-79(2009)Gorogh, T., et al. Int. J. Oncol. 33(5):1091-1098(2008)Kim, D.J., et al. Biochem. Biophys. Res. Commun. 373(4):521-527(2008)Weise, J.B., et al. Int. J. Oncol. 32(2):317-322(2008)
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