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LOXL4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96JB6 |
|---|---|
| Clone Names | 100712147 |
| Gene ID | 84171 |
|---|---|
| Other Names | Lysyl oxidase homolog 4, 143-, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C, LOXL4, LOXC |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LOXL4 |
|---|---|
| Synonyms | LOXC |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. |
| Cellular Location | Secreted, extracellular space. |
| Tissue Location | Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas Expressed in cartilage |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the lysyl oxidase genefamily. The prototypic member of the family is essential to thebiogenesis of connective tissue, encoding an extracellularcopper-dependent amine oxidase that catalyses the first step in theformation of crosslinks in collagens and elastin. A highlyconserved amino acid sequence at the C-terminus end appears to besufficient for amine oxidase activity, suggesting that each familymember may retain this function. The N-terminus is poorly conservedand may impart additional roles in developmental regulation,senescence, tumor suppression, cell growth control, and chemotaxisto each member of the family.
References
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Sebban, S., et al. Virchows Arch. 454(1):71-79(2009)Gorogh, T., et al. Int. J. Oncol. 33(5):1091-1098(2008)Kim, D.J., et al. Biochem. Biophys. Res. Commun. 373(4):521-527(2008)Weise, J.B., et al. Int. J. Oncol. 32(2):317-322(2008)
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