|Other Names||Glutamate receptor ionotropic, kainate 5, GluK5, Excitatory amino acid receptor 2, EAA2, Glutamate receptor KA-2, KA2, GRIK5, GRIK2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein|
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This gene encodes a protein that belongs to theglutamate-gated ionic channel family. Glutamate functions as themajor excitatory neurotransmitter in the central nervous systemthrough activation of ligand-gated ion channels and Gprotein-coupled membrane receptors. The protein encoded by thisgene forms functional heteromeric kainate-preferring ionic channelswith the subunits encoded by related gene family members. [providedby RefSeq].
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)Arai, S., et al. Psychiatr. Genet. 19(1):6-13(2009)Fotheringham, J., et al. J Neuroimmune Pharmacol 3(2):105-116(2008)Shibata, H., et al. Psychiatry Res 141(1):39-51(2006)
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