|Other Names||Oligoribonuclease, mitochondrial, 31--, RNA exonuclease 2 homolog, Small fragment nuclease, REXO2, SFN, SMFN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily =5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role in cellular nucleotide recycling.|
|Cellular Location||Isoform 1: Mitochondrion intermembrane space. Mitochondrion matrix Isoform 3: Cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
Nucleases are components of DNA and RNA metabolism thatcarry out functions in DNA repair, replication, and recombinationand in RNA processing and degradation. SFN is a homolog of Orn, a3-prime-to-5-prime exoribonuclease of E. coli that attacks the free3-prime hydroxyl group on single-stranded RNA, releasing 5-primemononucleotides in a sequential manner.
Young Park, A., et al. Protein Expr. Purif. 57(2):180-187(2008)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Ito, S., et al. Photochem. Photobiol. 80(2):281-285(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Nguyen, L.H., et al. J. Biol. Chem. 275(34):25900-25906(2000)
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