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REXO2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y3B8 |
|---|---|
| Clone Names | 100712256 |
| Gene ID | 25996 |
|---|---|
| Other Names | Oligoribonuclease, mitochondrial, 31--, RNA exonuclease 2 homolog, Small fragment nuclease, REXO2, SFN, SMFN |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | REXO2 |
|---|---|
| Synonyms | SFN, SMFN |
| Function | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022, PubMed:30926754, PubMed:32365187, PubMed:23741365). Binds and degrades longer oligonucleotides with a lower affinity (PubMed:31588022, PubMed:30926754, PubMed:32365187). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (PubMed:31588022, PubMed:30926754, PubMed:32365187). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (By similarity). |
| Cellular Location | Mitochondrion intermembrane space. Mitochondrion matrix. Mitochondrion. Cytoplasm. Nucleus |
| Tissue Location | Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Nucleases are components of DNA and RNA metabolism thatcarry out functions in DNA repair, replication, and recombinationand in RNA processing and degradation. SFN is a homolog of Orn, a3-prime-to-5-prime exoribonuclease of E. coli that attacks the free3-prime hydroxyl group on single-stranded RNA, releasing 5-primemononucleotides in a sequential manner.
References
Young Park, A., et al. Protein Expr. Purif. 57(2):180-187(2008)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Ito, S., et al. Photochem. Photobiol. 80(2):281-285(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Nguyen, L.H., et al. J. Biol. Chem. 275(34):25900-25906(2000)
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