|Other Names||TBC1 domain family member 1, TBC1D1, KIAA1108|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity).|
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TBC1D1 is the founding member of a family of proteinssharing a 180- to 200-amino acid TBC domain presumed to have a rolein regulating cell growth and differentiation. These proteins sharesignificant homology with TRE2 (USP6; MIM 604334), yeast Bub2, andCDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[suppliedby OMIM].
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)Must, A., et al. Neuromolecular Med. 11(1):13-19(2009)
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