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ESX1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N693 |
|---|---|
| Clone Names | 110726053 |
| Gene ID | 80712 |
|---|---|
| Other Names | Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1-N, Homeobox protein ESX1-C, ESX1, ESX1L, ESX1R |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ESX1 |
|---|---|
| Synonyms | ESX1L, ESX1R |
| Function | May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584} Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm |
| Tissue Location | Expressed in placenta and testis. Expressed in testicular germ cell tumors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a dual-function 65 kDa protein thatundergoes proteolytic cleavage to produce a 45 kDa N-terminalfragment with a paired-like homeodomain and a 20 kDa C-terminalfragment with a proline-rich domain. The C-terminal fragmentlocalizes to the cytoplasm while the N-terminal fragment localizesexclusively to the nucleus. In contrast to human, the mouse homologhas a novel PN/PF motif in the C-terminus and is paternallyimprinted in placental tissue. This gene likely plays a role inplacental development and spermatogenesis.
References
Bonaparte, E., et al. Hum. Reprod. 25(6):1398-1403(2010)Wang, X., et al. Hum. Mol. Genet. 16(17):2053-2060(2007)Loschiavo, M., et al. Mamm. Genome 18(1):75-85(2007)Murthi, P., et al. Mol. Hum. Reprod. 12(5):335-340(2006)Yanagihara, M., et al. Oncogene 24(38):5878-5887(2005)
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