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ESX1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8N693
Clone Names 110726053
Peptide ID 110726053
Additional Information
Gene ID 80712
Other Names Homeobox protein ESX1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1-N, Homeobox protein ESX1-C, ESX1, ESX1L, ESX1R
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESX1
Synonyms ESX1L, ESX1R
Function May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Cellular Location Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm
Tissue Location Expressed in placenta and testis. Expressed in testicular germ cell tumors.
Research Areas
Citations (0)

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This gene encodes a dual-function 65 kDa protein thatundergoes proteolytic cleavage to produce a 45 kDa N-terminalfragment with a paired-like homeodomain and a 20 kDa C-terminalfragment with a proline-rich domain. The C-terminal fragmentlocalizes to the cytoplasm while the N-terminal fragment localizesexclusively to the nucleus. In contrast to human, the mouse homologhas a novel PN/PF motif in the C-terminus and is paternallyimprinted in placental tissue. This gene likely plays a role inplacental development and spermatogenesis.


Bonaparte, E., et al. Hum. Reprod. 25(6):1398-1403(2010)Wang, X., et al. Hum. Mol. Genet. 16(17):2053-2060(2007)Loschiavo, M., et al. Mamm. Genome 18(1):75-85(2007)Murthi, P., et al. Mol. Hum. Reprod. 12(5):335-340(2006)Yanagihara, M., et al. Oncogene 24(38):5878-5887(2005)

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$ 80.00
Cat# BP17259a
Availability: In Stock
Bulk Size
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