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IFRD2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q12894 |
|---|---|
| Clone Names | 110726096 |
| Gene ID | 7866 |
|---|---|
| Other Names | Interferon-related developmental regulator 2, Protein SKMC15, IFRD2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IFRD2 {ECO:0000303|PubMed:30355441, ECO:0000312|HGNC:HGNC:5457} |
|---|---|
| Function | Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation (PubMed:30355441). Associates with the P- and E-sites of the ribosome and inserts a C- terminal helix into the mRNA exit channel to preclude translation (By similarity). |
| Tissue Location | Expressed in many tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
IFRD2 contains a predicted bipartite nuclear localization signal and an armadillo-beta catenin-like repeat. It is highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis.
References
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :Lerman, M.I., et al. Cancer Res. 60(21):6116-6133(2000)Buanne, P., et al. Genomics 51(2):233-242(1998)Latif, F., et al. Hum. Genet. 99(3):334-341(1997)
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