|Other Names||AP-4 complex subunit beta-1, AP-4 adaptor complex subunit beta, Adaptor-related protein complex 4 subunit beta-1, Beta subunit of AP-4, Beta4-adaptin, AP4B1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The heterotetrameric adaptor protein (AP) complexes sortintegral membrane proteins at various stages of the endocytic andsecretory pathways. AP4 is composed of 2 large chains, beta-4(AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4(AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM607243).
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Cayrol, C., et al. Biochem. Biophys. Res. Commun. 298(5):720-730(2002)Takatsu, H., et al. Biochem. Biophys. Res. Commun. 284(4):1083-1089(2001)Hirst, J., et al. Mol. Biol. Cell 10(8):2787-2802(1999)Dell'Angelica, E.C., et al. J. Biol. Chem. 274(11):7278-7285(1999)
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