|Other Names||AP-4 complex subunit beta-1, AP-4 adaptor complex subunit beta, Adaptor-related protein complex 4 subunit beta-1, Beta subunit of AP-4, Beta4-adaptin, AP4B1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.|
|Cellular Location||Golgi apparatus, trans-Golgi network. Membrane, coated pit Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The heterotetrameric adaptor protein (AP) complexes sortintegral membrane proteins at various stages of the endocytic andsecretory pathways. AP4 is composed of 2 large chains, beta-4(AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4(AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM607243).
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Cayrol, C., et al. Biochem. Biophys. Res. Commun. 298(5):720-730(2002)Takatsu, H., et al. Biochem. Biophys. Res. Commun. 284(4):1083-1089(2001)Hirst, J., et al. Mol. Biol. Cell 10(8):2787-2802(1999)Dell'Angelica, E.C., et al. J. Biol. Chem. 274(11):7278-7285(1999)
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