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NMNAT2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BZQ4
Clone Names 110717126
Peptide ID 110717126
Additional Information
Gene ID 23057
Other Names Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2, NMNAT2, C1orf15, KIAA0479
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NMNAT2 (HGNC:16789)
Function Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity).
Cellular Location Golgi apparatus membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8BNJ3}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasm. Cell projection, axon {ECO:0000250|UniProtKB:Q8BNJ3}. Note=Delivered to axons with Golgi-derived cytoplasmic vesicles {ECO:0000250|UniProtKB:Q8BNJ3}
Tissue Location Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
Research Areas
Citations (0)

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This gene product belongs to the nicotinamidemononucleotide adenylyltransferase (NMNAT) enzyme family, membersof which catalyze an essential step in NAD (NADP) biosyntheticpathway. Unlike the other human family member, which is localizedto the nucleus, and is ubiquitously expressed; this enzyme iscytoplasmic, and is predominantly expressed in the brain. Twotranscript variants encoding different isoforms have been found forthis gene.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lau, C., et al. J. Biol. Chem. 285(24):18868-18876(2010)Sorci, L., et al. Biochemistry 46(16):4912-4922(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Berger, F., et al. J. Biol. Chem. 280(43):36334-36341(2005)

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$ 80.00
Cat# BP17277a
Availability: In Stock
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