|Other Names||Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2, NMNAT2, C1orf15, KIAA0479|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+).|
|Cellular Location||Cytoplasm. Golgi apparatus|
|Tissue Location||Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the nicotinamidemononucleotide adenylyltransferase (NMNAT) enzyme family, membersof which catalyze an essential step in NAD (NADP) biosyntheticpathway. Unlike the other human family member, which is localizedto the nucleus, and is ubiquitously expressed; this enzyme iscytoplasmic, and is predominantly expressed in the brain. Twotranscript variants encoding different isoforms have been found forthis gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lau, C., et al. J. Biol. Chem. 285(24):18868-18876(2010)Sorci, L., et al. Biochemistry 46(16):4912-4922(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Berger, F., et al. J. Biol. Chem. 280(43):36334-36341(2005)
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