|Other Names||Pleckstrin homology domain-containing family G member 5, PH domain-containing family G member 5, Guanine nucleotide exchange factor 720, GEF720, PLEKHG5, KIAA0720|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell junction Cell projection, lamellipodium. Note=Predominantly cytoplasmic, however when cells are stimulated found in perinuclear regions. Localized at cell-cell junctions in quiescent endothelial cells, it relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (By similarity).|
|Tissue Location||Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.|
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This gene encodes a protein that activates the nuclearfactor kappa B (NFKB1) signaling pathway. Multations in this genehave been found in a family with distal spinal muscular atrophy.
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)Maystadt, I., et al. Am. J. Hum. Genet. 81(1):67-76(2007)Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)
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