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PLEKHG5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O94827
Clone Names 100603236
Peptide ID 100603236
Additional Information
Gene ID 57449
Other Names Pleckstrin homology domain-containing family G member 5, PH domain-containing family G member 5, Guanine nucleotide exchange factor 720, GEF720, PLEKHG5, KIAA0720
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0720
Function Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q66T02}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q66T02}. Cell membrane {ECO:0000250|UniProtKB:Q66T02}. Cell junction {ECO:0000250|UniProtKB:Q66T02}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q66T02}. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane. Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells. {ECO:0000250|UniProtKB:Q66T02}
Tissue Location Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.
Research Areas
Citations (0)

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This gene encodes a protein that activates the nuclearfactor kappa B (NFKB1) signaling pathway. Multations in this genehave been found in a family with distal spinal muscular atrophy.


Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)Maystadt, I., et al. Am. J. Hum. Genet. 81(1):67-76(2007)Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :Matsuda, A., et al. Oncogene 22(21):3307-3318(2003)

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$ 80.00
Cat# BP17282a
Availability: In Stock
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