|Other Names||Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2, SIGLEC10, SLG2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Single-pass type I membrane protein Isoform 5: Secreted.|
|Tissue Location||Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation) Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells|
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Provided below are standard protocols that you may find useful for product applications.
SIGLECs are members of the immunoglobulin superfamily thatare expressed on the cell surface. Most SIGLECs have 1 or morecytoplasmic immune receptor tyrosine-based inhibitory motifs, orITIMs. SIGLECs are typically expressed on cells of the innateimmune system, with the exception of the B-cell expressed SIGLEC6(MIM 604405).
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Kivi, E., et al. Blood 114(26):5385-5392(2009)Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Kitzig, F., et al. Biochem. Biophys. Res. Commun. 296(2):355-362(2002)
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