|Other Names||Probable ATP-dependent RNA helicase DDX4, DEAD box protein 4, Vasa homolog, DDX4, VASA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in germ cell development. May play a role in sperm motility.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region|
|Tissue Location||Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.|
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Provided below are standard protocols that you may find useful for product applications.
DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of this familyare believed to be involved in embryogenesis, spermatogenesis, andcellular growth and division. This gene encodes a DEAD box protein,which is a homolog of VASA proteins in Drosophila and several otherspecies. The gene is specifically expressed in the germ celllineage in both sexes and functions in germ cell development.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Tilgner, K., et al. Stem Cells 28(1):84-92(2010)Sugimoto, K., et al. J. Hum. Genet. 54(8):450-456(2009)Hashimoto, H., et al. Gynecol. Oncol. 111(2):312-319(2008)Albamonte, M.S., et al. Hum. Reprod. 23(8):1895-1901(2008)Guo, X., et al. Asian J. Androl. 9(3):339-344(2007)
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