SPATA2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UM82 |
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Clone Names | 110617275 |
Gene ID | 9825 |
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Other Names | Spermatogenesis-associated protein 2, Spermatogenesis-associated protein PD1, SPATA2, KIAA0757, PD1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SPAT2 |
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Function | Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). |
Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q66HP6} Note=Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells. |
Tissue Location | Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level) (PubMed:10222154, PubMed:11079456). Low expression in spleen, thymus and prostate (PubMed:10222154). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SPATA2 may have a role in the regulation of spermatogenesis.
References
Matsuzaki, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(17):7875-7880(2010)Sauce, D., et al. J. Virol. 83(18):9068-9078(2009)Capon, F., et al. Hum. Mol. Genet. 17(13):1938-1945(2008)Liliana Slongo, M., et al. Biochim. Biophys. Acta 1625(2):192-196(2003)Deloukas, P., et al. Nature 414(6866):865-871(2001)
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