|Other Names||Protein phosphatase methylesterase 1, PME-1, PPME1, PME1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.|
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Provided below are standard protocols that you may find useful for product applications.
Protein phosphatase methylesterase-1 catalyzes thedemethylation of the protein phosphatase-2A catalytic subunit(PPP2CA; MIM 176915) (Ogris et al., 1999 [PubMed10318862]).
Puustinen, P., et al. Cancer Res. 69(7):2870-2877(2009)Longin, S., et al. Exp. Cell Res. 314(1):68-81(2008)Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)Ogris, E., et al. J. Biol. Chem. 274(20):14382-14391(1999)
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