|Other Names||NMDA receptor synaptonuclear signaling and neuronal migration factor, Nasal embryonic luteinizing hormone-releasing hormone factor, Nasal embryonic LHRH factor, NSMF, NELF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.|
|Cellular Location||Nucleus. Nucleus envelope. Nucleus membrane Nucleus matrix. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium Associates with transcriptionally active chromatin regions Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity).|
|Tissue Location||Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is involved in guidanceof olfactory axon projections and migration of luteinizinghormone-releasing hormone neurons. Defects in this gene are a causeof idiopathic hypogonadotropic hypogonadism (IHH). Severaltranscript variants encoding different isoforms have been found forthis gene.
Xu, N., et al. Mol. Cell. Endocrinol. 319 (1-2), 47-55 (2010) :Trarbach, E.B., et al. Clin. Endocrinol. (Oxf) 72(3):371-376(2010)Yung, T.M., et al. Exp. Cell Res. 315(10):1693-1705(2009)Pedersen-White, J.R., et al. Mol. Hum. Reprod. 14(6):367-370(2008)Lim, J., et al. Cell 125(4):801-814(2006)
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