|Other Names||Tumor necrosis factor receptor superfamily member 21, Death receptor 6, CD358, TNFRSF21, DR6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase- 6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been shown to activateNF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through itsdeath domain, this receptor interacts with TRADD protein, which isknown to serve as an adaptor that mediates signal transduction ofTNF-receptors. Knockout studies in mice suggested that this geneplays a role in T-helper cell activation, and may be involved ininflammation and immune regulation.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Klima, M., et al. Biochim. Biophys. Acta 1793(10):1579-1587(2009)Nikolaev, A., et al. Nature 457(7232):981-989(2009)Otowa, T., et al. J. Hum. Genet. 54(2):122-126(2009)DeRosa, D.C., et al. Cancer Immunol. Immunother. 57(6):777-787(2008)
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