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PRDM5 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NQX1
Clone Names 100617209
Additional Information
Gene ID 11107
Other Names PR domain zinc finger protein 5, 211-, PR domain-containing protein 5, PRDM5, PFM2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDM5
Synonyms PFM2
Function Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.
Cellular Location Nucleus
Tissue Location Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a transcription factorof the PR-domain protein family. It contains a PR-domain andmultiple zinc finger motifs. Transcription factors of the PR-domainfamily are known to be involved in cell differentiation andtumorigenesis.

References

Cheng, H.Y., et al. J. Cancer Res. Clin. Oncol. 136(12):1821-1825(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Duan, Z., et al. Mol. Cell. Biol. 27(19):6889-6902(2007)Watanabe, Y., et al. Clin. Cancer Res. 13(16):4786-4794(2007)

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$ 277.78
Cat# BP17297a
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Availability: 2 weeks
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