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LMBR1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WVP7
Clone Names 100623213
Additional Information
Gene ID 64327
Other Names Limb region 1 protein homolog, Differentiation-related gene 14 protein, LMBR1, C7orf2, DIF14
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMBR1
Synonyms C7orf2, DIF14
Function Putative membrane receptor.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Widely expressed with strongest expression in heart and pancreas.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the LMBR1-like membraneprotein family. Another member of this protein family has beenshown to be a lipocalin transmembrane receptor. A highly conserved,cis-acting regulatory module for the sonic hedgehog gene is locatedwithin an intron of this gene. Consequently, disruption of thisgenic region can alter sonic hedgehog expression and affect limbpatterning, but it is not known if this gene functions directly inlimb development. Mutations and chromosomal deletions andrearrangements in this genic region are associated with acheiropodyand preaxial polydactyly, which likely result from altered sonichedgehog expression.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Farooq, M., et al. Eur. J. Hum. Genet. 18(6):733-736(2010)Rutsch, F., et al. Nat. Genet. 41(2):234-239(2009)He, F., et al. PLoS ONE 3 (8), E2948 (2008) :Wang, Z.Q., et al. Biochem. Biophys. Res. Commun. 355(2):312-317(2007)

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$ 277.78
Cat# BP17299c
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