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CIAPIN1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6FI81
Clone Names 100712039
Additional Information
Gene ID 57019
Other Names Anamorsin {ECO:0000255|HAMAP-Rule:MF_03115}, Cytokine-induced apoptosis inhibitor 1 {ECO:0000255|HAMAP-Rule:MF_03115}, Fe-S cluster assembly protein DRE2 homolog {ECO:0000255|HAMAP-Rule:MF_03115}, CIAPIN1 {ECO:0000255|HAMAP-Rule:MF_03115}
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIAPIN1 {ECO:0000255|HAMAP-Rule:MF_03115}
Function Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity).
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:16957168, ECO:0000269|PubMed:29848660}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:16957168} Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:21700214}
Tissue Location Ubiquitously expressed. Highly expressed in heart, liver and pancreas.
Research Areas
Citations (0)
citation

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Background

CIAPIN1 is a cytokine-induced inhibitor of apoptosis withno relation to apoptosis regulatory molecules of the BCL2 (MIM151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 isdependent on growth factor stimulation (Shibayama et al., 2004[PubMed 14970183]).

References

He, L., et al. Cancer Lett. 276(1):88-94(2009)Zhang, Y., et al. Mol. Cell. Biol. 28(18):5569-5582(2008)Li, X., et al. Carcinogenesis 29(8):1587-1593(2008)Hao, Z., et al. Int. J. Biol. Macromol. 42(1):27-32(2008)Li, X., et al. Mol. Biol. (Mosk.) 42(1):102-109(2008)

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$ 277.78
Cat# BP17300c
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