CADM3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N126 |
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Clone Names | 100712283 |
Gene ID | 57863 |
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Other Names | Cell adhesion molecule 3, Brain immunoglobulin receptor, Immunoglobulin superfamily member 4B, IgSF4B, Nectin-like protein 1, NECL-1, Synaptic cell adhesion molecule 3, SynCAM3, TSLC1-like protein 1, TSLL1, CADM3, IGSF4B, NECL1, SYNCAM3, TSLL1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CADM3 |
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Synonyms | IGSF4B, NECL1, SYNCAM3, TSLL1 |
Function | Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q99N28}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99N28} Cell junction {ECO:0000250|UniProtKB:Q99N28} |
Tissue Location | Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IGSF4B is a brain-specific protein related to thecalcium-independent cell-cell adhesion molecules known as nectins(see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed15741237]).
References
Yin, B., et al. Chin. Med. Sci. J. 25(2):100-104(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Raveh, S., et al. J. Cell. Biochem. 108(1):326-336(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Dong, X., et al. J. Biol. Chem. 281(15):10610-10617(2006)
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