|Other Names||Cell adhesion molecule 3, Brain immunoglobulin receptor, Immunoglobulin superfamily member 4B, IgSF4B, Nectin-like protein 1, NECL-1, Synaptic cell adhesion molecule 3, SynCAM3, TSLC1-like protein 1, TSLL1, CADM3, IGSF4B, NECL1, SYNCAM3, TSLL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||IGSF4B, NECL1, SYNCAM3, TSLL1|
|Function||Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).|
|Cellular Location||Cell junction. Cell membrane; Single-pass type I membrane protein Note=Localized at the cell-cell attached sites of the plasma membrane.|
|Tissue Location||Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.|
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IGSF4B is a brain-specific protein related to thecalcium-independent cell-cell adhesion molecules known as nectins(see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed15741237]).
Yin, B., et al. Chin. Med. Sci. J. 25(2):100-104(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Raveh, S., et al. J. Cell. Biochem. 108(1):326-336(2009)Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)Dong, X., et al. J. Biol. Chem. 281(15):10610-10617(2006)
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