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Mouse Tgfbr2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q62312
Clone Names 110328125
Additional Information
Gene ID 21813
Other Names TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, Tgfbr2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tgfbr2
Function Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P37173}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P37173} Membrane raft {ECO:0000250|UniProtKB:P37173}
Tissue Location Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus
Research Areas
Citations (0)
citation

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.

References

Droguett, R., et al. Exp. Cell Res. 316(15):2487-2503(2010)Robson, A., et al. Dev. Dyn. 239(9):2435-2442(2010)Moreno, S.G., et al. Dev. Biol. 342(1):74-84(2010)Ouyang, W., et al. Immunity 32(5):642-653(2010)Lu, L., et al. J. Immunol. 184(8):4295-4306(2010)

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$ 277.78
Cat# BP17322b
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