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Mouse Tlk1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8C0V0 |
|---|---|
| Clone Names | 110328128 |
| Gene ID | 228012 |
|---|---|
| Other Names | Serine/threonine-protein kinase tousled-like 1, Tousled-like kinase 1, Tlk1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Tlk1 |
|---|---|
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed in all tissues examined. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).
References
Canfield, C., et al. BMC Mol. Biol. 10, 110 (2009) :Taniwaki, T., et al. Dev. Growth Differ. 47(3):163-172(2005)Sunavala-Dossabhoy, G., et al. BMC Mol. Biol. 6, 19 (2005) :Cobellis, G., et al. Nucleic Acids Res. 33 (4), E44 (2005) :Okazaki, N., et al. DNA Res. 11(3):205-218(2004)
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