|Other Names||Acyloxyacyl hydrolase, Acyloxyacyl hydrolase small subunit, Acyloxyacyl hydrolase large subunit, AOAH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides.|
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes both the light and heavy subunits ofacyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysisof acyloxylacyl-linked fatty acyl chains from bacteriallipopolysaccharides, effectively detoxifying these molecules. Theencoded protein may play a role in modulating host inflammatoryresponse to gram-negative bacteria. Alternatively splicedtranscript variants have been described.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)Barnes, K.C., et al. J. Allergy Clin. Immunol. 118(1):70-77(2006)Coulthard, M.G., et al. Infect. Immun. 64(5):1510-1515(1996)Staab, J.F., et al. J. Biol. Chem. 269(38):23736-23742(1994)
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