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WDR68 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P61962 |
|---|---|
| Clone Names | 110617062 |
| Gene ID | 10238 |
|---|---|
| Other Names | DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog, DCAF7, HAN11, WDR68 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DCAF7 |
|---|---|
| Synonyms | HAN11, WDR68 |
| Function | Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. |
| Cellular Location | Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
WDR68 is involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
References
Ritterhoff, S., et al. EMBO J. 29(22):3750-3761(2010)Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Morita, K., et al. J. Dermatol. Sci. 44(1):11-20(2006)Jin, J., et al. Mol. Cell 23(5):709-721(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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