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KLHL12 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q53G59
Clone Names 110617103
Peptide ID 110617103
Additional Information
Gene ID 59349
Other Names Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog, hDKIR, KLHL12, C3IP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL12
Synonyms C3IP1
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
Cellular Location Cytoplasmic vesicle, COPII-coated vesicle
Tissue Location Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland
Research Areas
Citations (0)

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Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.


Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Rondou, P., et al. J. Biol. Chem. 283(17):11083-11096(2008)Lim, J., et al. Cell 125(4):801-814(2006)Angers, S., et al. Nat. Cell Biol. 8(4):348-357(2006)Uchida, K., et al. Immunology 116(1):53-63(2005)

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$ 80.00
Cat# BP17327b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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