|Other Names||Nucleoporin Nup43, Nup107-160 subcomplex subunit Nup43, p42, NUP43|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.|
|Cellular Location||Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex|
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Provided below are standard protocols that you may find useful for product applications.
Bidirectional transport of macromolecules between thecytoplasm and nucleus occurs through nuclear pore complexes (NPCs)embedded in the nuclear envelope. NPCs are composed ofsubcomplexes, and NUP43 is part of one such subcomplex, Nup107-160(Loiodice et al., 2004 [PubMed 15146057]).
Zuccolo, M., et al. EMBO J. 26(7):1853-1864(2007)Glavy, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(10):3811-3816(2007)Loiodice, I., et al. Mol. Biol. Cell 15(7):3333-3344(2004)Le Rouzic, E., et al. J. Biol. Chem. 277(47):45091-45098(2002)Cronshaw, J.M., et al. J. Cell Biol. 158(5):915-927(2002)
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