|Other Names||Sorting nexin-18, SH3 and PX domain-containing protein 3B, Sorting nexin-associated Golgi protein 1, SNX18, SH3PXD3B, SNAG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.|
|Cellular Location||Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin- coated pits at a late stage of clathrin-coated vesicle formation|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. This protein does not contain a coiled coil region,like some family members, but contains a SH3 domain. Multipletranscript variants encoding different isoforms have been found forthis gene.
Park, J., et al. J. Cell. Sci. 123 (PT 10), 1742-1750 (2010) :Voss, M., et al. BMC Immunol. 10, 53 (2009) :Haberg, K., et al. J. Cell. Sci. 121 (PT 9), 1495-1505 (2008) :Thornhill, P.B., et al. FEBS Lett. 581(23):4455-4462(2007)Seet, L.F., et al. Biochim. Biophys. Acta 1761(8):878-896(2006)
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