|Other Names||Potassium voltage-gated channel subfamily S member 3, Delayed-rectifier K(+) channel alpha subunit 3, Voltage-gated potassium channel subunit Kv93, KCNS3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328).|
|Tissue Location||Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328).|
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Voltage-gated potassium channels form the largest and mostdiversified class of ion channels and are present in both excitableand nonexcitable cells. Their main functions are associated withthe regulation of the resting membrane potential and the control ofthe shape and frequency of action potentials. The alpha subunitsare of 2 types: those that are functional by themselves and thosethat are electrically silent but capable of modulating the activityof specific functional alpha subunits. The protein encoded by thisgene is not functional by itself but can form heteromultimers withmember 1 and with member 2 (and possibly other members) of theShab-related subfamily of potassium voltage-gated channel proteins.This gene belongs to the S subfamily of the potassium channelfamily.
Nyholt, D.R., et al. Hum. Mol. Genet. 17(21):3318-3331(2008)van Es, M.A., et al. Nat. Genet. 40(1):29-31(2008)Schymick, J.C., et al. Lancet Neurol 6(4):322-328(2007)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Kerschensteiner, D., et al. Proc. Natl. Acad. Sci. U.S.A. 102(17):6160-6165(2005)
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