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NARF Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UHQ1
Clone Names 110617269
Peptide ID 110617269
Additional Information
Gene ID 26502
Other Names Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Cellular Location Nucleus.
Tissue Location Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.
Research Areas
Citations (0)

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Several proteins have been found to be prenylated andmethylated at their carboxyl-terminal ends. Prenylation wasinitially believed to be important only for membrane attachment.However, another role for prenylation appears to be its importancein protein-protein interactions. The only nuclear proteins known tobe prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteineresidue of a carboxyl-terminal CaaX motif. Thispost-translationally modified cysteine residue is removed fromprelamin A when it is endoproteolytically processed into maturelamin A. The protein encoded by this gene binds to the prenylatedprelamin A carboxyl-terminal tail domain. It may be a component ofa prelamin A endoprotease complex. The encoded protein is locatedin the nucleus, where it partially colocalizes with the nuclearlamina. It shares limited sequence similarity with iron-onlybacterial hydrogenases. Alternatively spliced transcript variantsencoding different isoforms have been identified for this gene,including one with a novel exon that is generated by RNA editing.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Moller-Krull, M., et al. J. Mol. Biol. 382(3):601-609(2008)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :Lattanzi, G., et al. J. Cell. Biochem. 102(5):1149-1159(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)

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$ 80.00
Cat# BP17343c
Availability: In Stock
Bulk Size
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