Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
NARF Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UHQ1 |
|---|---|
| Clone Names | 110617269 |
| Gene ID | 26502 |
|---|---|
| Other Names | Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NARF |
|---|---|
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Several proteins have been found to be prenylated andmethylated at their carboxyl-terminal ends. Prenylation wasinitially believed to be important only for membrane attachment.However, another role for prenylation appears to be its importancein protein-protein interactions. The only nuclear proteins known tobe prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteineresidue of a carboxyl-terminal CaaX motif. Thispost-translationally modified cysteine residue is removed fromprelamin A when it is endoproteolytically processed into maturelamin A. The protein encoded by this gene binds to the prenylatedprelamin A carboxyl-terminal tail domain. It may be a component ofa prelamin A endoprotease complex. The encoded protein is locatedin the nucleus, where it partially colocalizes with the nuclearlamina. It shares limited sequence similarity with iron-onlybacterial hydrogenases. Alternatively spliced transcript variantsencoding different isoforms have been identified for this gene,including one with a novel exon that is generated by RNA editing.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Moller-Krull, M., et al. J. Mol. Biol. 382(3):601-609(2008)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :Lattanzi, G., et al. J. Cell. Biochem. 102(5):1149-1159(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
