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TRAF3IP3 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y228
Clone Names 110617278
Additional Information
Gene ID 80342
Other Names TRAF3-interacting JNK-activating modulator, TRAF3-interacting protein 3, TRAF3IP3, T3JAM
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRAF3IP3
Synonyms T3JAM
Function Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'- dependent ubiquitination of TBK1 (PubMed:32366851).
Cellular Location Cell membrane. Golgi apparatus membrane; Single-pass type IV membrane protein. Lysosome membrane {ECO:0000250|UniProtKB:Q8C0G2}. Mitochondrion outer membrane. Note=Accumulates on the mitochondria after virus infection.
Research Areas
Citations (0)
citation

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Background

The gene encodes a protein that mediates cell growth bymodulating the c-Jun N-terminal kinase signal transduction pathway.The encoded protein may also interact with a large multiproteinassembly containing the phosphatase 2A catalytic subunit. [providedby RefSeq].

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Goudreault, M., et al. Mol. Cell Proteomics 8(1):157-171(2009)Ma, X., et al. Life Sci. 81(14):1141-1151(2007)Dadgostar, H., et al. FEBS Lett. 553(3):403-407(2003)

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$ 277.78
Cat# BP17344a
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