|Other Names||High mobility group nucleosome-binding domain-containing protein 5, Nucleosome-binding protein 1, HMGN5, NSBP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.|
|Cellular Location||Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear protein with similarities tothe high mobility group proteins, HMG14 and HMG17, which suggeststhat this protein may function as a nucleosomal binding andtranscriptional activating protein.
Rochman, M., et al. Biochim. Biophys. Acta 1799 (1-2), 86-92 (2010) :Rochman, M., et al. Mol. Cell 35(5):642-656(2009)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)King, L.M., et al. Genomics 71(2):163-173(2001)
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